Backgroud

Allergens refer to a class of antigenic substances capable of triggering specific immune responses in the body, leading to physiological dysfunction or tissue damage. They primarily enter the human body through nasal or oral routes and can cause various allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and purpura. Allergic diseases are clinically prevalent and continue to rise due to environmental changes, dietary shifts, and other factors, posing a significant challenge in modern healthcare.

Immunoglobulin E (IgE) is a cell-bound antibody closely associated with hypersensitivity reactions. Among its subtypes, allergen-specific IgE binds to particular allergens and serves as a key biomarker for clinical allergen identification. Measuring IgE levels is critical for personalized diagnosis and management of allergic diseases.